Genetic counseling for men with recurrent pregnancy loss or recurrent implantation failure due to abnormal sperm chromosomal aneuploidy

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P-89: Recurrent Pregnancy Loss and Genetic Counseling

Background: Recurrent pregnancy loss (RPL) is a common and distressing disorder. RPL is a devastating reproductive problem affecting approximately 5% of couples trying to conceive. If we camper the rate of miscarriage in couples may experience RPL with the pregnancy loss rate in general population we may calculate that it is at least two or three times higher than expected. This study aimed to ...

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Fluorescence in situ hybridization detects increased sperm aneuploidy in men with recurrent pregnancy loss.

OBJECTIVE To investigate, in men presenting with recurrent pregnancy loss (RPL), the prevalence of sperm autosome and sex chromosome aneuploidy. DESIGN Retrospective study. SETTING Male infertility clinic. PATIENT(S) A total of 140 men with RPL provided semen samples, and five normozoospermic controls provided 140 semen samples for comparison. Recurrent pregnancy loss, documented in the f...

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I-24: Recurrent Implantation Failure

Recurrent implantation failure (RIF) has many definitions, but usually authors consider RIF, the failure to achieve a pregnancy fallowing 2-6 IVF cycles in which more than 10 high grade embryos were transferred to the uterus. There are a lot of causes for RIF but two main causes of that are related to embryo and endometrium. Chromosomal abnormalities, zona hardening and problems in culture medi...

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Sperm DNA fragmentation, recurrent implantation failure and recurrent miscarriage

Evidence is increasing that the integrity of sperm DNA may also be related to implantation failure and recurrent miscarriage (RM). To investigate this, the sperm DNA fragmentation in partners of 35 women with recurrent implantation failure (RIF) following in vitro fertilization, 16 women diagnosed with RM and seven recent fathers (control) were examined. Sperm were examined pre- and post-densit...

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Genetic Factors Associated with Recurrent Pregnancy Loss

Recurrent pregnancy loss (RPL) also referred to as recurrent miscarriage or recurrent spontaneous abortion has been a cause for bad obstetric history along with still births, intrauterine fetal deaths and intrauterine growth retardation (IUGR). According to the Practice Committee of the American Society for Reproductive Medicine, for epidemiological studies, three or more pregnancy losses are c...

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ژورنال

عنوان ژورنال: Journal of Assisted Reproduction and Genetics

سال: 2016

ISSN: 1058-0468,1573-7330

DOI: 10.1007/s10815-016-0702-8